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Van der Dussen continued his impressive start to international cricket with 50 not out, his third half-century in his first four innings in ODIs. He clubbed a six to go to his 50 and win the game at Newlands as South Africa ended on 241-3, overhauling Pakistan's 240-8 with 10 overs to spare.
Du Plessis also finished 50 not out. Their unbroken 95-run partnership saw South Africa home but opener Quinton de Kock set it up with his rapid 83 from 58 balls at the top of the order.
Pakistan's below-par total came after being put in to bat by South Africa. Fakhar Zaman top-scored with 70 and Imad Wasim made late runs for his 47 not out off 31 deliveries.
It wasn't enough to stop South Africa winning a seesaw series. South Africa was 1-0 down, then 2-1 up before Pakistan leveled and sent it to a decider in Cape Town.
South Africa also won the test series.Scorecard
Pakistan
Imam-ul-Haq c Pretorius b Steyn 8
Fakhar Zaman c Imran Tahir b Phehlukwayo 70
Babar Azam b Pretorius 24
Mohammad Hafeez c De Kock b Phehlukwayo 17
Shoaib Malik run out (Pretorius) 31
Mohammad Rizwan c De Kock b Pretorius 10
Shadab Khan c Van der Dussen b Mulder 19
Imad Wasim not out 47
Mohammad Amir b Rabada 6
Shaheen Shah Afridi not out 0
Extras (b1, lb1, w6) 8
Total (8 wkts, 50 overs) 240
Did not bat: Usman Shinwari
Fall: 1-8, 2-64, 3-108, 4-128, 5-147, 6-174, 7-200, 8-221
Bowling: Steyn 8-0-51-1 (1w), Imran Tahir 10-0-36-0, Rabada 10-1-43-1 (1w), Pretorius 10-1-46-2, Mulder 3-0-20-1 (1w), Phehlukwayo 9-0-42-2 (3w)
South Africa
Q. de Kock c sub (Hasan Ali) b Shinwari 83
H. Amla c Mohammad Rizwan b Afridi 14
R. Hendricks c Afridi b Amir 34
F. du Plessis not out 50
H. van der Dussen not out 50
Extras (lb1, nb1, w8) 10
Total (3 wkts, 40 overs) 241
Did not bat: W. Mulder, D. Pretorius, A. Phehlukwayo, K. Rabada, D. Steyn, Imran Tahir
Fall: 1-39, 2-100, 3-146
Bowling: Usman Shinwari 7-0-43-1 (1nb, 1w), Shaheen Shah Afridi 7-0-34-1 (2w), Mohammad Amir 8-0-40-1 (1w), Shadab Khan 10-0-78-0, Mohammad Hafeez 1-0-7-0, Imad Wasim 7-0-38-0 (1w)
Result: South Africa won by seven wickets
Series: South Africa won the five-match series 3-2
Toss: South Africa
Umpires: Gregory Brathwaite (WIN), Adrian Holdstock (RSA)
TV umpire: Paul Reiffel (AUS)
Match referee: Ranjan Madugalle (SRI)
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