"I hear a lot of perplexity and fear coming from Spain and they're acting like nothing is wrong," De Laurentiis said. "What does it take to say, 'Don't go to Barcelona but rather go to Portugal, Germany or Geneva?'"
The Barcelona-Napoli game is scheduled for Aug. 8. The first leg of the round-of-16 encounter finished 1-1 in Naples in February. The winner will advance to the quarterfinals in Lisbon, Portugal.
The Barcelona-Napoli game was originally scheduled for March 18 before being postponed amid the coronavirus lockdown.
"If they've decided to play the Champions League in Portugal and the Europa League in Germany, I think we can go to Portugal or Germany for the round of 16," De Laurentiis said. "I don't understand why it should stay in a city that has a really critical situation."
Players at Spanish clubs Sevilla, Real Madrid and Zaragoza recently tested positive for Covid-19.
Madrid plays at Manchester City on Aug. 7 in the Champions League, while Sevilla is scheduled to face Roma in the Europa League next Thursday in Duisburg, Germany.
Spanish Health Minister Salvador Illa said Thursday that 60% of Spain's recent uptick in infections are in the northeast regions of Catalonia, whose biggest city is Barcelona, and neighboring Aragon.
"The outbreak (in Barcelona) is worrying because of the density of the population," Illa said. "(But) what is happening in Spain is happening in all the other countries in our region. This is a pandemic. We are on alert and acting appropriately. The majority of the outbreaks in Spain are under control."
When Uefa announced three weeks ago that the Champions League quarterfinals, semifinals and final would be played with single-elimination games in Lisbon, it also announced a Plan B for the round-of-16 games, saying they could also be moved to Portugal.
The stadiums listed for Uefa's backup plan are Estadio do Dragao in Porto and Estadio Dom Afonso Henriques in Guimaraes.
The temblor was recorded near the Kilauea volcano; aftershocks are expected, say officials
The yellow metal has seen a steep upward rise, hitting a six-month peak