National security spokesperson to continue pressing for a temporary ceasefire that Washington wants to last for at least six weeks
Large multi-country trials of the combination HIV drug lopinavir/ritonavir to treat Covid-19 have recruited thousands of patients and the World Health Organization is now looking at interim data, the UN agency's chief scientist said.
Several thousand patients had been enrolled in the lopinavir/ritonavir arm of the WHO-led Solidarity Trial and in a separate UK-led Covid-19 trial of the drug combination.
"This is already a huge number and should be enough to tell us whether this drug is actually having a mortality benefit or a benefit on disease severity," she said.
Another arm of the WHO-led trial, looking at the potential effect of Gilead's antiviral drug remdesivir in Covid-19, might need more patients, she said.
"(We are) looking at ways to maximise the generation of knowledge about drugs which are promising," she said. "On the drug remdesivir, we still do not have a definitive answer on its impact on mortality - which is what we would like to see."
The Solidarity Trial started out with five arms looking at possible treatment approaches to Covid-19: standard care; remdesivir; the malaria drug hydroxychloroquine; the HIV drugs lopinavir/ritonavir; and lopanivir/ritonavir combined with interferon.
"We will come back very soon on further decisions on the Solidarity Trial. It's an adaptive design - you can change and adapt as you go on," Swaminathan said.
On Wednesday the WHO stopped the arm testing hydroxychloroquine as a treatment for Covid-19 patients, after studies indicated it showed no benefit in those who have the disease.
National security spokesperson to continue pressing for a temporary ceasefire that Washington wants to last for at least six weeks
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