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At least 45 people were killed and 110 wounded on Sunday in three bomb blasts near the revered shrine of Sayyida Zeinab outside the Syrian capital Damascus, state media said.
State news agency SANA said the first blast was caused by a car bomb that detonated at a bus station near the shrine.
It said two suicide bombers then detonated their explosive belts when people gathered at the scene.
An AFP photographer at the scene said the blasts caused massive damage, shattering windows and ripping a huge crater in the road.
Smoke rose from the twisted carcasses of more than a dozen cars and a bus damaged in the blasts, as ambulances ferried away the wounded and firefighters worked to put out blazes started by the bombings.
In February 2015, two suicide attacks killed four people and wounded 13 at a checkpoint near the shrine.
There was no immediate claim of responsibility for Sunday's attack.
The area around the shrine is heavily secured with regime checkpoints set up hundreds of metres away to prevent vehicles from getting close to Sayyida Zeinab.
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