Hard-hitting Aryna Sabalenka meanwhile burnished her title credentials as she barrelled through, along with several other women's seeds
Serbia's Novak Djokovic hits a return against Bulgaria's Grigor Dimitrov during their men's singles match of the Australian Open in Melbourne on Saturday. —AFP
Novak Djokovic's hamstring just about held up as the hot favourite battled into the Australian Open last 16 on Saturday, but Andy Murray's heroic run is over.
Hard-hitting Aryna Sabalenka meanwhile burnished her title credentials as she barrelled through, along with several other women's seeds.
An ailing Djokovic had heavy strapping and needed treatment twice on his troublesome left hamstring before defeating Grigor Dimitrov 7-6 (9/7), 6-3, 6-4 on Rod Laver Arena.
The Serb will face home hope Alex de Minaur for a place in the quarterfinals as he closes on a 10th Melbourne Park crown and a record-equalling 22nd Grand Slam title.
"Obviously, I didn't know how I'm going to feel physically, it was going up and down," said Djokovic.
"It was an incredible battle, three sets over three hours. Let's rest up and prepare for the next one."
Djokovic's fellow 35-year-old Murray will not join him in the next round, however, as the Briton's 4:05 am finish eventually caught up with him.
Former No.1 Murray was clearly feeling the effects of his epic five-setter in round two, which started on Thursday but ended in the early hours of Friday.
The 24th-seeded Spaniard Roberto Bautista Agut won 6-1, 6-7 (7/9), 6-3, 6-4 and faces unseeded Tommy Paul of the United States.
"I gave everything that I had the last three matches -- I'm very proud of that," said Murray.
"But I'm also disappointed because I put loads of work into the beginning of this year and was playing well enough to have a really good run, have a deep run."
Also in the men's draw, fifth seed Andrey Rublev surged into a clash with Holger Rune -- then thanked his beaten opponent Dan Evans for giving him a banana mid-match.
The Russian crushed the Briton 6-4, 6-2, 6-3 to make the fourth round for a third time.
He will face Danish teenager Rune for a place in the quarter-finals after the ninth seed survived a nasty fall to sweep past unseeded Frenchman Ugo Humbert 6-4, 6-2, 7-6 (7/5).
His friend and 25th seed Evans threw a banana to Rublev at a changeover when he ran out.
"I didn't ask him, I asked the ball boy, but Danny asked for bananas earlier and he had two so he just said 'take it', and I caught it," said Rublev.
In two all-American matches, Jeffrey Wolf strolled past Michael Mmoh in three sets while Paul made equally light work of Jenson Brooksby.
Sabalenka is building a head of steam in her pursuit of a first Grand Slam title.
The Belarusian fifth seed blew away 26th-seeded Elise Mertens 6-2, 6-3 to set up a clash with Olympic champion Belinda Bencic.
Thirtieth seed Karolina Pliskova and 23rd seed Zhang Shuai also went through in straight sets on day six at Melbourne Park, and will clash in the fourth round.
Sabalenka is trying not to get carried away.
The Minsk-born 24-year-old teased the Margaret Court Arena crowd for supporting Belgium's Mertens over her, but said she was enjoying the ride into the second week.
"About the favourite, that I am on that favourite list... I mean, it's really good that I'm there," said the Belarusian, who is yet to drop a set.
"But I better focus on myself, on my game, make sure that my dream will happen."
Bencic has also not dropped a set in Melbourne. The Swiss 12th seed eased past unseeded Italian Camila Giorgi 6-2, 7-5.
Also into the fourth round is the 17-year-old Linda Fruhvirtova, who beat her fellow Czech Marketa Vondrousova in three sets. She faces Donna Vekic of Croatia.
"It feels pretty surreal," the teenager told reporters.
"It's an incredible feeling. I'm just so happy and excited to be able to say: 'Hi second week!'"
French fourth seed Caroline Garcia fought back after a disastrous first set to beat world number 158 Laura Siegemund 1-6, 6-3, 6-3.
RESULTS
Men's singles (Third round)
Andrey Rublev (RUS x5) bt Daniel Evans (GBR x25) 6-4, 6-2, 6-3
Holger Rune (DEN x9) bt Ugo Humbert (FRA) 6-4, 6-2, 7-6 (7/5)
Alex De Minaur (AUS x22) bt Benjamin Bonzi (FRA) 7-6 (7/0), 6-2, 6-1
Novak Djokovic (SRB x4) bt Grigor Dimitrov (BUL x27) 7-6 (9/7), 6-3, 6-4
Ben Shelton (USA) bt Alexei Popyrin (AUS) 6-3, 7-6 (7/4), 6-4
Jeffrey Wolf (USA) bt Michael Mmoh (USA) 6-4, 6-1, 6-2
Roberto Bautista Agut (ESP x24) bt Andy Murray (GBR) 6-1, 6-7 (7/9), 6-3, 6-4
Tommy Paul (USA) bt Jenson Brooksby (USA) 6-1, 6-4, 6-3
Women's singles (Third round)
Karolina Pliskova (CZE x30) bt Varvara Gracheva (RUS) 6-4, 6-2
Zhang Shuai (CHN x23) bt Katie Volynets (USA) 6-3, 6-2
Magda Linette (POL) bt Ekaterina Alexandrova (RUS x19) 6-3, 6-4
Caroline Garcia (FRA x4) bt Laura Siegemund (GER) 1-6, 6-3, 6-3
Aryna Sabalenka (BLR x5) bt Elise Mertens (BEL x26) 6-2, 6-3
Belinda Bencic (SUI x12) bt Camila Giorgi (ITA) 6-2, 7-5
Donna Vekic (CRO) bt Nuria Parrizas Diaz (ESP) 6-2, 6-2
Linda Fruhvirtova (CZE) bt Marketa Vondrousova (CZE) 7-5, 2-6, 6-3