The story of a non-resident Bangladeshi family establishing and running the famed perfume company Al Haramain and its successful subsidiaries
"This is our World Cup final. That's how important it is for us," Ledesma said of Saturday's clash in Tokyo Pool C, the so-called pool of death which also includes France as well as Tonga and the USA.
Argentina were narrowly beaten 23-21 by France and another loss would put them out of the tournament before the quarter-finals for the first time since 2003.
"If we win this game, we're in the quarter-finals. That's how big this game is," Ledesma said.
Fly-half Sanchez, so often a match-winner for Los Pumas, has been left out of the match-day 23 for the first time in three years.
Castres pivot Benjamin Urdapilleta will wear the 10 jersey with Lucas Mensa, a natural centre who has only played one Test, providing cover.
The in-form Julian Montoya, who scored three tries against Tonga, remains at hooker with former captain Creevy on the bench where he is poised to make his 88th Test appearance and overtake the previous Argentina record held by former fly-half Felipe Contepomi.
"When we selected the team we think about the best team possible to win the game. It's nothing negative," Ledesma said.
"England is a candidate for the title. They've been saying that for the last four years. Eddie Jones has been saying it. They have a lot of resources, a great team, but I'm confident it's going to be really hard for them to beat us.
"It's a really good opportunity to get into the history books of Argentinian rugby."
Ledesma, a hooker with the Argentine side that made the 2007 World Cup semi-finals and beat France in the play-off for third, said telling Sanchez he was not required was one of the toughest decisions he has made to make as coach.
"I told Nico before I announced the team and it was very hard. But the most important thing is the team and everyone has to contribute even if they are left out of the 23.
"It is an important game, the most important of recent times for this team."
Argentina have had an impressive run at the World Cup since 2007, making the quarter-finals four years later and finishing fourth in 2015.
"It is a unique opportunity for this group to enter the great history of Los Pumas," the coach said.
"In the history of the team there must be 20 matches that stand out and this would be one more."
Argentina (15-1)
Emiliano Boffelli; Matias Moroni, Matias Orlando, Jeronimo De La Fuente, Santiago Carreras; Benjamin Urdapilleta, Tomas Cubelli; Javier Ortega Desio, Marcos Kremer, Pablo Matera (capt); Tomas Lavanini, Guido Petti; Juan Figallo, Julian Montoya, Nahuel Tetaz Chaparro
Replacements:
Agustin Creevy, Mayco Vivas, Santiago Medrano, Matias Alemanno, Tomas Lezana, Felipe Ezcurra, Lucas Mensa, Bautista Delguy
The story of a non-resident Bangladeshi family establishing and running the famed perfume company Al Haramain and its successful subsidiaries
Matches will be played on an exclusive Saturday with no Premier League fixtures taking place on the same day
The plant to be set up in Al Bihouth area is expected to process 900,000 tonnes of waste into energy
The minor didn't take his cellphone or wallet, assuming he'd return quickly
Nadal, 37, who missed virtually all of the 2023 season, is hoping to compete at the French Open in May where he is the record 14-time champion
A Good Samaritan offered him a ride to Bur Dubai for free, declining Sahni's attempt to offer payment
Passengers with cancelled bookings will receive a full credit voucher for the amount paid
Passengers must go to the airport only if they have a confirmed reservation