It is a tale of love and dedication scripted in the heart of Abu Dhabi
Bayern coach Hansi Flick said Coman would be replaced either by Ivan Perisic or Philippe Coutinho.
Bayern won the first leg 3-0 in London back in February.
Coman, who had trained alone on Thursday, has been nursing a minor muscle injury. Bayern are also without injured defender Benjamin Pavard.
Chelsea also have their share of injuries with more than half a dozen players out.
"Chelsea have a very good squad with a lot of depth," Flick told a virtual news conference.
"I know the youth work in England and how they have been bringing out many good young players in recent years. They have a team where they can cover positions with young players. We are prepared for that."
Bayern, who are chasing a treble of titles after winning the domestic double, are returning to action after their German Cup final victory on July 4.
"We cannot be too relaxed despite our (3-0) advantage from the first leg," captain Manuel Neuer said. "We had a short break. We know we have a good starting position but it is a restart for us. So we want to start with a good game.
"At home we want to win against Chelsea."
The Champions League quarter-finals, which will be decided over one leg rather than the usual two, will begin in Lisbon next Wednesday when Atalanta take on Paris St Germain.
RB Leipzig face Atletico Madrid the following day with the other two last-eight ties taking place next Friday and Saturday.
It is a tale of love and dedication scripted in the heart of Abu Dhabi
The event brought together key players in the polo community to celebrate a successful season and honour outstanding achievements
In the first two days after the torrential rain on Tuesday, around 1,244 flights were cancelled
There has been fear that decades of enmity between the two could spill over into all-out war
The leading hypermarket chain has implemented additional measures to ensure sufficient stock availability for shoppers
Thousands of personnel deployed to clear accumulated water, clogged drains, and fallen trees
Areas such as Abu Shagara, Al Qasimiya, King Faisal Road, Al Mahatta, and Majaz have been particularly affected
The Ministry of Foreign Affairs reiterated its call on the United Nations and the UN Security Council to fulfill their responsibilities