She fired a two-under 70 to reach 12 under after four rounds at the St. Charles Country Club.
Shin Ji-yai of South Korea shot a one-over 73 and tied for second with American Kristy McPherson (66), defending champion Suzann Pettersen of Norway (69) and Young Jee Lee from South Korea (69).
Heading into the final round Wie and Shin were tied for the lead.
Wie collected 337,500 dollars for winning the LPGA’s only stop in Canada.
Integrating the youth could open doors for new ideas and perspectives