The evening was a resounding success, boasting delectable cuisine, a lively ambiance, and impeccable service
The efficacy of third doses of the Pfizer and Moderna mRNA vaccines wanes substantially by the fourth month after administration, a new study by the US Centers of Disease Control and Prevention (CDC) said on Friday.
Though it’s now well documented that vaccine efficacy goes down after two doses, relatively little has been published on the duration of protection after a booster.
The new study was based on more than 241,204 visits to the emergency department or an urgent care clinic, and 93,408 hospitalisations, which are more serious, among adults with Covid-19-like illness during August 26, 2021-January 22, 2022.
Vaccine efficacy was estimated by comparing the odds of a positive Covid test between vaccinated and unvaccinated patients and using statistical methods to control for calendar week, geographic area, while adjusting for age, the level of local transmission, and patient characteristics like comorbidities.
ALSO READ:
During the Omicron-predominant period, vaccine efficacy against Covid-associated emergency department or urgent care visits was 87 per cent during the two months after a third dose, but fell to 66 per cent by the fourth month.
Vaccine efficacy against hospitalisation was 91 per cent in the first two months, but fell to 78 per cent by the fourth month after a third dose.
“The finding that protection conferred by mRNA vaccines waned in the months after receipt of a third vaccine dose reinforces the importance of further consideration of additional doses to sustain or improve protection,” the authors concluded.
Speaking at a White House Covid briefing on Wednesday, President Joe Biden’s top medical advisor Anthony Fauci said it was likely that fourth doses would more likely be needed for subsets of people who mount weaker immune responses, such as the elderly and immunocompromised.
In a separate development on Friday, the Food and Drug Administration (FDA) authorised a new lab-grown antibody treatment by pharmaceutical company Lilly called bebtelovimab.
The drug is administered as an intravenous injection over at least 30 seconds and has been green lighted for the treatment of mild-to-moderate Covid among people 12 and over at high risk of severe disease.
Data supporting the authorisation came from a clinical trial that showed the drug has strong promise against Omicron. Lilly’s previous antibody treatment was de-authorised by the FDA after it was found to be ineffective against this variant.
The evening was a resounding success, boasting delectable cuisine, a lively ambiance, and impeccable service
Reds defeat at Everton extinguishes their last hopes of winning the Premier League
The destination was to originally close on April 28
The cashback is valid until May 12
Both BJP and Congress raised allegations of causing hatred and division based on religion, caste, community, or language
The zoo found international notoriety in 2016 when the singer Cher launched a campaign to remove its shackled Asian elephant Kaavan
It is expected to roll out preventive and proactive strategies, train and qualify specialists, and prepare scientific research and forecasting studies
A wave of exceptionally hot weather has blasted parts of South and Southeast Asia this week