The evening was a resounding success, boasting delectable cuisine, a lively ambiance, and impeccable service
As part of both the pulmonary and inflammatory phases, the immune system is "supercharged" and secretes in the blood numerous cytokines, particularly interleukin (IL)-6, which induces further inflammation.
Tocilizumab is a monoclonal antibody, which binds and blocks the interleukin (IL)-6 receptor and helps damper the inflammatory response.
The activity of tocilizumab was first shown in chimeric antigen receptor (CAR) T-cell therapy, where a similar phenomenon of overactive and growing T cells induce a "cytokine storm."
This provided a rationale to try tocilizumab in Covid-19 patients.
The findings showed a statistically significant decrease in hospital-related deaths among the patients who received the tocilizumab.
A roughly 36 per cent decrease in hospital-related mortality among the ICU patients who received the drug, as compared with patients in the ICU who didn't receive it.
Importantly, it appeared that higher levels of a blood test marker of inflammation, C-reactive protein, could predict which ICU patients might benefit most from the tocilizumab therapy, potentially allowing doctors to tailor therapy to those most in need.
"These real-time findings have helped to point us the way forward," the study authors wrote.
Earlier this month, another study published in the International Journal of Infectious Diseases, found that t patients experiencing severe Covid-19 symptoms had improved outcomes when administered an Interleukin-6 (IL6ri) inhibitor, sarilumab or tocilizumab.
The evening was a resounding success, boasting delectable cuisine, a lively ambiance, and impeccable service
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