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A timeline: Pfizer's record breaking 9 month sprint to Covid-19 vaccine

IANS/New York
Filed on November 20, 2020 | Last updated on November 20, 2020 at 09.13 pm
Photo: Alamy

Pfizer announced on Friday it is seeking emergency approval from US regulators for its Covid-19 vaccine, which has shown 95 percent efficacy in a totality of two data sets released in the last 10 days. The chief of the Trump administration's Operation Warp Speed vaccine programme says all systems are ready to ensure the vaccines get to states as soon as they figure out their distribution plan.

Seen purely from a clock time perspective, Pfizer's dash to the finish line has broken all vaccine development speed records, and on a totally new technology platform called mRNA - which has no benchmarks yet.

The coronavirus itself isn't there inside the mRNA vaccine. Instead, it is embedded with a piece of genetic code that trains our bodies to recognize imminent enemy action from the spike protein on the surface of the virus. When the mRNA enters our cells, it begins to spew copies of the coronavirus' spike protein. That prompts the immune system to churn out antibodies against the virus. In virology, generating neutralising antibodies is a good surrogate of our bodies' ability to protect from sickness.

Below is a timeline of Pfizer's run up to this historic moment:

March 17: Pfizer and BioNTech announce plans to develop a Covid-19 vaccine using BioNTech's technology platform.

April 29: Testing of four vaccine candidates begins with volunteers in Germany. Five other countries are part of the testing pool.

May 5: Testing expands to include the US.

July 1: One of four vaccine candidates appears to rev up the immune system, is well tolerated.

July 22: Trump administration agrees to buy 100 million vaccine doses, with an option for 500 million more.

July 27: Late-stage testing begins for 30,000 volunteers.

September 8: CEOs of 9 pharma giants, including Pfizer and BioNTech, pledge they will not be rushed by politics or extraneous factors.

November 8: Pfizer receives data from independent trial monitors who analyse test results.

November 9: Pfizer announces the vaccine appears to be about 90 per cent effective, based on 94 infections in a pool of more than 43,000 volunteers.

November 18: Pfizer and BioNTech release a second batch of interim results saying their two-dose coronavirus vaccine candidate is 95 per cent effective and also protects the most vulnerable people in older age groups from the risk of dying from the virus.

Nov 20: Pfizer announces intent to submit application to US regulators for emergency use authorisation.





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