The couple, who previously released the hit Nobody But You in 2019 as well as 2016's Go Ahead and Break My Heart, is set to debut Happy Anywhere, they announced on Friday.
The country music single is being described as a "loving, feel-good" song.
The 44-year-old singer Shelton said in a statement: "Even though Gwen and I just had a single out we decided that, under the circumstances, this year... man, there's never been a better time for Happy Anywhere."
He continued: "We've all been in quarantine and lockdown and hopefully we've been doing that with somebody that we really love and enjoy being around. That's what happened with Gwen and me this summer - and this entire year."
In April, the pair's Nobody But You, became the No. 1 single on the Billboard Country Airplay chart. It was also Stefani's first-ever country song.
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