Chemotherapy likely to get less painful

(IANS)
Filed on June 25, 2014
Chemotherapy likely to get less painful

The pain pathway is dependent on activation of S1PR1 in the central nervous system.

Chemotherapy likely to get less painful (/assets/oldimages/chemo_25062014.jpg)In a major breakthrough that has long term implications for cancer patients, researchers have discovered the pain pathway in chemotherapy and also a potential way to block it.

Saint Louis University professor of pharmacological and physiological sciences Daniela Salvemini found a molecular pathway by which a painful chemotherapy side effect happens and a drug that may be able to stop it.

“The chemotherapy drug paclitaxel is widely used to treat many forms of cancer, including breast, ovarian and lung cancers,” said Salvemini.

“Though it is highly effective, the medication, like many other chemotherapy drugs, is frequently accompanied by a debilitating side effect called chemotherapy induced peripheral neuropathy, or CIPN,” she added.

In addition to causing suffering to patients, CIPN is often a limiting factor when it comes to treatment.

Salvemini and her colleagues studied paclitaxel, which is also known as Taxol, and discovered that the pain pathway is dependent on activation of S1PR1 in the central nervous system.

This engages a series of damaging neuro-inflammatory processes leading to pain.

By inhibiting this molecule, they found that they could block and reverse paclitaxel-induced neuropathic pain without interfering with the drug’s anti-cancer effects.

The study appeared in the Journal of Biological Chemistry.





 
 
khaleejtimes
khaleejtimes

Video | Nation

KT One-on-One: UAE Minister Dr Thani bin...
khaleejtimes
khaleejtimes

Video | Nation

UAE Covid vaccine: How to get free Pfizer...
khaleejtimes
khaleejtimes

Video | Videos

KT explains: WhatsApp vs Telegram vs Signal
khaleejtimes
khaleejtimes

Video | News Bulletins

News in a Minute: Top headlines of January 11
khaleejtimes
khaleejtimes

Video | Nation

UAE's Hidden Gems: Forever Rose Cafe at...
khaleejtimes
khaleejtimes

Video | Nation

When KT went hunting for ice in the desert
khaleejtimes
khaleejtimes

Video | News Bulletins

KT Morning Chat: UAE leaders want...
khaleejtimes
khaleejtimes

Video | News Bulletins

KT Morning Chat: 250,000 UAE residents get...
khaleejtimes
khaleejtimes

Video | Nation

World Leaders who have got the Covid-19...