Aid groups warn any invasion would add to already-catastrophic conditions for Gaza's 2.4 million people
"This month, I end my three years as US Ambassador to Qatar. It has been the greatest honour of my life...," Dana Shell Smith said on Twitter on Tuesday.
Shell Smith did not say why she was stepping down, if she was staying within the diplomatic service or who would replace her.
Many US ambassadors leave their posts after serving around three years.
Her departure comes with Washington sending mixed signals over the Gulf crisis, which saw Saudi Arabia and several of its allies cut ties with Qatar claiming that Doha supported extremist groups. Qatar rejects the allegations.
US President Donald Trump has signalled his support for the Saudi-led move but other US officials have been more cautious and called for dialogue to end the crisis.
Shell Smith was appointed ambassador to the country by Barack Obama in 2014. Last month she appeared to express dissatisfaction with political events back home in another message posted on social media.
She took to Twitter in the hours after Trump's dramatic sacking of FBI director James Comey, tweeting: "Increasingly difficult to wake up overseas to news from home, knowing I will spend today explaining our democracy and institutions."
Aid groups warn any invasion would add to already-catastrophic conditions for Gaza's 2.4 million people
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